Xin Chen1，Haijin Chen1，Zhiqin Liu2，Cailing Chen1，Fenping Luo1，Zhichun Feng1*

1 Department of Pediatrics, Bayi Children’s Hospital Affiliated with Beijing Military Region General Hospital, Beijing  100710, China
2 Department of Nuclear Medicine, Beijing Military Region General Hospital, Beijing  100710, China 

Corresponding author: Dr. Zhichun Feng, Chief physician, Bayi Children’s Hospital Affiliated with Beijing Military Region General Hospital, Beijing 100710，China

摘要：纳入1例表皮葡萄球菌脑膜炎并发急性播散性脑脊髓炎的9岁女性患儿。患儿以“持续高热伴头痛5d，抽搐1次”入院。查体有意识障碍，脑膜刺激征阳性。脑脊液提示细胞数和蛋白水平增高，脑脊液培养见表皮葡萄球菌生长。经静滴头孢类抗生素、降颅压和静推地塞米松3周后，抽搐和发热症状改善，但意识障碍、肌无力和双侧肢体瘫痪显著。化验脑脊液IgG指数升高，寡克隆带阳性，头颅核磁共振影像学检查提示脑白质非对称性T2长信号，符合急性播散性脑脊髓炎。经大剂量甲强龙3d和丙种球蛋白冲击治疗6d后，体温恢复正常，头痛消失，脑脊液有了显著改善。说明此例患儿为表皮葡萄球菌感染相关的急性播散性脑脊髓炎，提示表皮葡萄球菌感染可能是急性播散性脑脊髓炎的致病因素，急性播散性脑脊髓炎是本例表皮葡萄球菌脑膜炎的并发症。

关键词：急性播散性脑脊髓炎；表皮葡萄球菌感染；儿童 

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